Get Ready to Press Bearish Buttons

The immediate outlook for long-term buyers looks dour
Stocks opened lower Monday following a weekend of new concerns over Greece’s likely exit from the European Union. Europe’s major bourses closed sharply lower, and debt yields rose as the euro fell against other major currencies including the dollar.


At the close, the Dow Jones Industrial Average fell 125 points to 12,695, the S&P 500 lost 15 points at 1,338, and the Nasdaq was down 31 points to 2,903. The NYSE traded 802 million shares and the Nasdaq crossed 449 million. On the NYSE, decliners outnumbered advancers by 5-to-1, and on the Nasdaq decliners were ahead by 3-to-1.

The not-so-new headline “Greece May Be Out” was back again, and with it came a rush to the dollar. I use the PowerShares US Dollar Fund (NYSE:UUP) as a convenient benchmark for viewing the dollar vs. a package of foreign currencies. Yesterday the dollar was under enormous buying pressure and by executing a “break-away-gap” confirmed last week’s upside break of the UUP’s intermediate resistance line. The gap up is a powerful signal that demand for the dollar will continue, and thus UUP should head higher. Unfortunately, there is an inverse relationship between a higher dollar and other investments like stocks and various commodities.

The decline from 1,343 to 1,338 might be only five points, but its technical significance is much greater. The support zone at 1,343 to 1,357 was formed over a month (February to early March), and yet the selling pressure of just one week cracked the hard-fought support zone. This breakdown changes the intermediate trend to down from sideways and sets up the market for further selling.

Taking a broader view of the S&P 500 shows a band of support at 1,264 to 1,292. This is the target of the current decline. It is calculated by taking the high of the year, 1,422, and subtracting from it the recently failed support zone numbers. In the lower half of the target zone is the 200-day moving average, now at 1,277. In a major breakdown, the stochastic (internal indicator), though oversold, could remain oversold for weeks.


Conclusion: Technically, the stock market is in a short- and intermediate-term decline, but the overall, long-term trend remains up. The market is highly volatile, and any positive headline from Europe could result in a sharp rally. However, we must go with the charts, and this new breakdown means that to stabilize the downtrend, buyers would have to drive prices north of 1,357. Instead, yesterday’s breakdown looks like the beginning of another selloff. Long-term buyers should hold cash and only buy quality stocks on days with sharp selloffs. Speculators should be selling short or initiating highly leveraged bearish strategies.

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An unexpected boom is quietly sweeping its way across remote areas of America. And making many people a fortune in the process...

Whether it’s Ohio farmers cashing in monthly checks for $35,000... or North Dakota truckers pocketing more cash than they ever dreamed of, a lot of people are starting to make a lot of money.

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It will soon affect ALL Americans — you... your neighbor... the 17 year old flipping burgers at McDonald’s... everyone — in a way few people thought possible.

One major news outlet called it “a development that holds profound implications for the economy of the US and its status as superpower.” A government advisor group stated, “This is very big and it’s coming on very fast.” And a major financial newspaper declared it has “already minted a half-dozen billionaires — comparable to the riches brought by the internet.”

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An Electrifying Biotechnology

A Shot at Shocking Profits
By Patrick Cox


Fascination with the effects of electricity on the body goes back — way back.

In the 1770s Italian physician and physicist Luigi Galvani shocked the world with the discovery that a spark could cause a dead frog’s legs to twitch.

In 1802, German chemist Johann Wilhelm Ritter furthered Galvani’s research into electrophysiology. He observed how halting a strong current in muscle nerves could cause a muscle to contract.

Electricity as a medical therapy became a high-voltage field of interest. By the late 1800s, scientific literature described how electrical pulses could kill bacteria in river water or change the shape and color of red blood cells. Luminaries, such as Nikola Tesla, pioneered experiments and patented electrotherapeutic equipment.

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Although electricity’s effect on the body had long been studied by the middle of the 20th century, many of the mechanisms were not yet known. In the 1950s, however, this began to change. For example, in 1951 Nobel Laureate in physiology or medicine Alan Lloyd Hodgkin theorized that the breakdown of a cell’s “skin” was at the root of many of electricity’s observed effects.

Hodgkin believed cellular membranes were electrically insulating layers, and that strong electricity caused pores to permanently open. Irreversibly opening pores made cells break apart and die. The phenomenon was dubbed electroporation, from the words “electric” and “pore.”

However, more experiments by other researchers eventually showed that irreversible electroporation wasn’t always the outcome of passing electricity through cells. Cellular pores are electrically charged gates. If pulses of electrical energy are sufficiently low and brief, existing gates open only temporarily. These cells don’t die, but this effect can still be useful. With electroporation, the ability of cellular membranes to keep a tight seal to the outside world can be manipulated for short periods of time.

As it turns out, the discovery of reversible electroporation revolutionized biotechnology research. Cracking open a cell’s pores allows researchers to get stuff into cells they weren’t able to before. By the 1980s, thanks to reversible electroporation, researchers were able to modify genes in everything from mouse cells to bacteria.

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Today, electroporation equipment is a standard appliance in research labs. These devices, called electroporators, are used to create things like “knockout mice” — organisms with genes modified to study everything from cancer compounds to Alzheimer’s disease. Moreover, many of the new wonder drugs are biologics, which means they are produced by living organisms. Biologics often depend on the use of electroporation to create genetically modified cell lines to manufacture complex therapeutic proteins.

Up until recently electroporation has been limited to the lab. It is something used to introduce molecules that normally won’t be absorbed by cells while in culture. But that has changed...

Today this same technology is being applied for the treatment of cancer in living organisms — humans, to be exact...

You may already be familiar with some of this technology. I’ve been writing about it for some time.

Therapeutic engineered DNA molecules, known as plasmids, are an exciting, maturing platform for treating disease.

Plasmids are small rings of DNA that are used to turn cells into custom protein manufacturing plants. Once introduced into a cell, these genetic code constructs act like native DNA: they guide the production of proteins. This can include therapeutic proteins. The downside of DNA plasmids as agents to cure disease, however, is that they don’t migrate into a cell’s interior very well, if at all.

Electroporation solves the problem of DNA delivery. It has been used for this job in labs for decades. It can increase the ability of molecules like DNA to enter cells by 1,000 times or more.

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Electroporation drug delivery can be used for far more than DNA vaccines. It can be used to deliver DNA designed for other purposes, as well as for improving the uptake of therapeutic molecules that are already on the market...

One use of gene therapies involves injecting directly into tumors.

This focuses on writing the code for these naturally occurring anti- cancer agents in its DNA plasmids, and then introduces them into tumor cells via electroporation.

Normally, the immune system works to seek and destroy cells that develop mutations. Sometimes, however, mutated cells develop the ability to defend themselves by hiding from the immune system. Alerting the immune system with these signaling proteins allows the immune system to recognize cancer cells and triggers a cascade reaction to destroy them.

Early investors in the technology will be on track to reap rich rewards from breakthrough electroporation platforms... it addresses a huge market.

Yours for transformational profits,

Patrick Cox 

How OLED Smashes Traditional Smart Screens

By Greg Guenthner
May 8, 2012

They call it the hammer test.

Researchers at electronics firms from Samsung to Sony have captivated audiences with their online OLED demonstrations. The setup is relatively simple. A researcher places a paper-thin, flexible OLED display on a table next to a traditional flat display. Then he breaks out a heavy mallet. After a single whack, the regular screen is completely destroyed.

The OLED display doesn’t react at all to the blow. It still works. Not even an attack from a sledge can mangle these next-generation displays.

You can find countless clips of twisted and abused OLEDs on YouTube. All of them end the same way: the traditional screens are ruined, while the OLEDs survive their beatings without a scratch.

But the hammer test is more than an interesting gimmick. These demonstrations actually prove how viable this futuristic display technology has become...

“The visual aspects of the breakthrough display technology are only part of the story,” says our own Ray Blanco.

“The market is expanding rapidly,” Ray explains. “This year, we also have some near-term catalysts to accelerate the touch screen business.”

Keep reading for Ray’s take on this extraordinary growth opportunity. And find out who will be the new market leaders as this sector continues to rise...

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Nothing Touches This Market...
By Ray Blanco

Last summer, I wrote about a new generation of display technology called OLED.

OLED display screens — short for organic light-emitting diodes — offer far greater energy efficiency, along with brilliant colors and durability.

I’ve seen video clips of mobile OLED screens being smashed with hammers and not looking the worse for wear. A standard LCD screen would shatter into dozens of shards. In addition, OLED allows for transparent and flexible screens, which opens up a new world of possibilities for display technology. CNNMoney’s site lists transparent screens as the big technology breakthrough of 2012, although they got the name of the technology wrong.

The visual aspects of a breakthrough display technology, however, are only part of the story...

Mobile devices bring additional challenges, requiring the application of additional technologies.

Mobile computing devices are, obviously, small. This complicates their use, since there isn’t much room to cram a display and keyboard interface onto them. As a solution to the problem, mobile devices have been dropping mechanical keyboards and moving to touch screens.

Screens are no longer just output devices. They are now input devices as well. Sharing input and output functions in the same physical space means display screens can be larger. That’s easier on the eyes. Touch screens are also easier and more intuitive for many mobile applications compared with toggles and trackballs.

Several types of touch-sensitive displays exist, but the most- popular variety today is known as the capacitive touch screen. A capacitive touch screen includes an insulating layer, like glass, that sits on top of a conducting layer. Current manufacturing techniques use indium tin oxide (ITO) for the conducting layer.

Touch screens allowing multiple simultaneous touches feature a coordinate grid layer of electrodes, which each act as a sensor. Since the human body conducts electricity, when the insulating glass layer is touched, a potential electrical difference is created between the finger (or thumb, as the case may be) and the ITO elements.

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This electrical phenomenon acts as a signal that is sent to a microcontroller, which interprets it so it can be used to sense input by a device’s operating system. Microcontroller functions include receiving the raw data, cleaning up background noise, interpreting the size and shape of the touch and calculating the exact coordinates of the touch. Touch has revolutionized the mobile computing market.

So just how big is the touch market? According to Walker Mobile, a mobile display market analysis and information firm, the touch screen market grew from $1.5 billion in annual revenues in 2008 to over $6 billion last year.

DisplaySearch, another market analysis firm, forecasts this market to grow to over $22 billion by 2016.


The market is expanding rapidly, and this year, we also have some near-term catalysts to accelerate the touch screen business.

Microsoft’s Windows 8, for example, will feature increased support for touch screens. Microsoft’s new user interface, called Metro, is specifically designed to use them. I had a chance to demo the Windows reboot at the Consumer Electronics Show earlier in the year. It is a big improvement over Microsoft’s initial attempts to include stylus touch functionality in tablet computers.

With the launch of Windows 8, there will be a wave of new touch- enabled mobile devices at the end of the year. However, we’ll also see touch interfaces accelerate their move into traditional computers.

Intel, always a close Microsoft partner, revealed an Ultrabook reference design that includes the tech. Ultrabooks are a highly portable, high-performance segment of the notebook market that is being promoted by Intel. They are expected to post strong growth within the PC segment over the next few years and will be a huge driver for touch screen technology.

With continuing strong growth in touch-enabled smartphones and tablets, as well as new touch-enabled PCs, there is a huge opportunity for companies in the touch screen business.

The semiconductor industry has been going through a soft patch, but it isn’t expected to be touch-and-go for much longer. With Windows 8, touch-enabled Ultrabooks and flexible touch screens all starting to go live by the end of the year as well, it is a great time to start a position in the touch screen market.

Ad lucrum per scientia (toward wealth through science),

Ray Blanco